阻塞性黄疸患者血液高凝状态探讨

An Analysis of the Blood Hypercoagulative State in Obstructive Jaundice Patients

通过检测15例OJ患者手术引流前及引流后第2、5、10日血浆中抗凝物质蛋白C(PC) ,凝血因子vW因子 (vWF)及血小板颗粒膜蛋白 (GMP-140)的含量变化。结果表明术前PC水平OJ组较对照组明显降低(P<0.05)。vWF及GMP-140明显增高(P<0.05)。术后vWF及GMP -140随PC的上升而下降并渐恢复到正常。OJ患者血液呈高凝状态 ,与肝损害、内毒素血症有关。

Fifteen obstructive jaundice patients' plasma levels of anticoagulative substance protein C(PC), coagulative factor vW factor(vWF) and platellete particle membrane protein(GMP-140).Are measured and compared. The result indicates that before the operation, the PC level is significantly lower(P<0.05),while the vWF and GMP-140 are higher(P<0.05). After the biliary drainage, with the PC level increasing, the vWF and GMP-140 levels rise to normal. These findings seem to lead to the conclusion that the hypercoagulative state of OJ patient is related to liver damage and endotoxemia and early biliary drainage is favarable to the elimination of the hypercoagulative state and the related complieations.