喹硫平对难治性抑郁症的辅助治疗

Auxiliary Effect of Quetiapine on Patients with Refractory Depression

目的探讨喹硫平治疗难治性抑郁症的增效作用及安全性。方法 60例难治性抑郁症患者分为喹硫平组(合用组)和舍曲林组(单用组)各30例。观察6周。于治疗前及治疗1、2、4和6周采用汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)评定疗效;以治疗中出现的症状量表(TESS)评定不良反应。结果两组治疗后HAMD和HAMA评分均较治疗前有显著差异(P<0.01);两组比较,以合用组评分显著较低(P<0.05)。两组治疗各周TESS评分差异均无统计学意义(P>0.05)。结论喹硫平治疗难治性抑郁症增效作用明显且安全。

Objective To explore the efficacy and safety of quetiapine augmentation of antidepressant on refractory depression.Methods A total of 60 patients with refractory depression were dividedinto quetiapine group（combined used group,n=30）and sertraline group（single used group,n=30）.The study lasted for 6 weeks.The efficacy and side effects were assessed with Hamilton depression scale（HAMD）,Hamilton anxiety scale（HAMA）and treatment emergent symptom scale（TESS）respectively at baseline,week l,2,4 and 6.Results The total scores of HAMD and HAMA were significantly decreased after treatment in two groups（P0.01）.The scores of combined used group were more decreased than the ones of single used group in two groups（P0.05）.There was no significant difference of TESS scores between two groups at each week（P0.05）.Conclusion Qaetiapine can be effective and safe in adjunctive treatment of patients with refractory depression.