枸橼酸坦度螺酮联合米氮平治疗老年期抑郁症的对照研究

Clinical Control Study of Combination Treatment of Tandospirone Citrate Tablets and Mirtazapine on Elderly Patients with Depression

目的观察枸橼酸坦度螺酮联合米氮平治疗老年期抑郁症的疗效和安全性。方法对符合CCMD-Ⅲ的抑郁症诊断标准的60例老年患者,随机分为枸橼酸坦度螺酮联合米氮平组和米氮平组,分别治疗。采用汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)和不良反应量表(TESS)分别观察疗效和不良反应,连续观察8周。结果在治疗第1周,2组HAMD和HAMA评分均下降,但2组间有显著性差异(P<0.05)。第2周末开始2组间HAMD和HAMA评分差异无显著性。第8周末2组显效率分别为93.3%和86.7%,差异无统计学意义(χ2=0.74,P>0.05)。结论枸橼酸坦度螺酮联合米氮平治疗老年期抑郁症起效更快,病人的满意度和依从性更好。

Objective To observe the effect of combination treatment of tandospirone citrate tablets and mirtazapine on depression in the elderly,and assess the safety.Methods A total of 60 adult patients were recruited in the study.All the cases were diagnosed as elderly patients with depression in accordance with the CCMD-Ⅲ diagnosis standard and randomized into two groups which were treated with for 8 weeks.Study group treated with combination of tandospirone citrate tablets and mirtazapine with thirty patients and control group treated with mirtazapine with 30 patients.Hamilton Depression Rating Scale（HAMD）,Hamilton Anxiety Scale（HAMA）and Treatment Emergent Side Effects Scale（TESS）were used for eight weeks to observe the effectiveness and adverse reactions.Results At the first treatment weekend,HAMD and HAMA scores were decreased in both groups and there were significant differences between two groups（P0.05）.After the second weekend,there were no significant differences between two groups in HAMD and HAMA scores.At the eight weekend,the effective rate of two groups were 93.3% and 86.7% respectively,without statistical differences（χ2=0.74,P0.05）.Conclusion Compared with mirtazapine,combination of tandospirone citrate tablets and mirtazapine in the treatment for depression in the elderly has faster and greater effectiveness with more patients＇ satisfaction and better compliance.