浅谈高通量透析的优势及护理体会

The advantages of high-flux dialysis and nursing

目的评价高通量透析治疗维持性血液透析患者的疗效。方法将60例规律血液透析患者随机分为普通PMMA膜透析器组、普通聚砜膜透析器组及高通量透析器组各20例。比较单次血液透析前后，3组患者血清β2-微球蛋白（β2-microglobulin，β2-MG）清除效果，以及6个月后的胆固醇、三酰甘油、低密度脂蛋白的变化情况。结果高通量透析器组以及应用PMMA膜的透析器组，透析后均能降低β2-MG的浓度，其中高通量透析器组更为显著。脂代谢方面，高通量透析器组患者透析后的血总胆固醇、三酰甘油及低密度脂蛋白水平明显下降，而普通透析器组无明显变化。结论高通量透析提高患者透析效率、生活质量，透析并发症明显减少。

Objective To evaluate the efficacy of the high-flux dialysis on maintaining hemodialysis patients. Methods 60 hemodialysis patients were randomly divided into the ordinary PMMA membrane dialyzer group, the ordinary polysulfone membrane dialyzer group and the high-flux dialyzer group with 20 patients in each group. Before and after the single hemodialysis, the removing effect of serum [32- mi- croglobulin （[32-MG）in the 3 kinds of dialyzer, and cholesterol, triglyceride, low density lipoprotein changes after 6 months were compared. Results The ordinary PMMA membrane dialyzer group and high-flux di- alyzer group can reduce the concentration of ~2-MG, while the high-flux dialyzer group showed more sig- nificant effect. On the aspect of lipid metabolism, in the high-flux dialyzer group, serum total cholesterol, triglycerides and LDL levels decreased significantly, while the ordinary dialysis group had no significant change. Conclusions The high-flux dialysis can improve the dialysis efficiency, life quality and reduce the complications of patients.