侧链含炔丙基的PLGA-PEG-PLGA三嵌段共聚物的合成与表征

Synthesis and Characterization of PLGA-PEG-PLGA Triblock Copolymer with Side Propargyl Groups

生物降解聚酯如聚乳酸（PLA）和聚羟基乙酸（PGA）及其共聚物聚（乳酸一羟基乙酸，PLGA）具有生物可降解性及良好的力学和加工性，在生物医药领域具有广泛的应用．但是这类材料疏水性强，缺乏可与细胞、蛋白产生特异性相互作用的功能性基团，其生物相容性不理想，因此需对其表面进行必要的生物学修饰．“点击化学”80是通过Cu（Ⅰ）催化炔基与叠氮基反应生成单一的反式三氮唑分子，属于1，3-双偶极Huisgen环加成反应．由于反应条件温和、快速、有效、高产率和高选择性，因此“点击化学”被应用于生物降解聚酯的改性归“引。

In order to introduce the propargyl groups to the side chains of biodegradable polyester which avai- lable for the attachment of functionality using ＂click＂ chemistry, the proparg-yl glycolide （PG） monomer was synthesized and characterized by FFIR and ^13C NMR. Then, a series of PLGA-PEG-PLGA tri-block copoly- mers with side propargyl groups was prepared by bulk ring-opening eopolymerization of L-lactide and propargyl glycolide using 1,4-dimethylaminopyridine（DMAP） as a catalyst and polyethylene glycol（PEG） as a cointia- tor with different feed ratios（ npEG ： npG ： nL-LA ）. The structure and properties of the PLGA-PEG-PLGA tri-block eopolymers with side propargyl groups were studied by FFIR, ^1H NMR and gel permeation chromatography.