2,5-二取代-1,3,4-噻二唑衍生物的合成与表征

Synthesis and Characterization of 2,5-Disubstituted-1,3,4-thiadiazole Derivatives

苯并噁唑啉酮和1,3,4-噻二唑衍生物具有多种生物活性,制备含有苯并噁唑啉酮结构的1,3,4-噻二唑衍生物非常有意义。本文以邻氨基苯酚和尿素为初始原料,经多步合成反应,制备了10个新的2-(芳甲酰氨基)-5-(2-苯并噁唑啉酮-3-甲基)-1,3,4-噻二唑化合物(7a～7j),并利用IR、1H NMR和元素分析对其结构进行了表征。

In view of various biological activities of benzoxazolinone and thiadiazole derivatives, the preparation of 1,3,4-thiadiazole derivatives containing benzoxazolinone moiety is of great significance. In this paper, ten novel 2- arylformylamino-5-（2-benzoxazolinone-3-yl） methyl-1,3,4-thiadiazoles （Ta -7j） were synthesized by 2-aminophenol and urea as the starting materials via a series of reactions. The structures of the target compounds were characterized by IR, 1H NMR and elemental analysis.