用核磁共振技术研究氢键的键合方式

NMR Study on the Hydrogen-bonding Motif

为了了解怎样利用核磁共振技术研究氢键的键合方式,本文以联酰胺衍生物为例,分别运用变温核磁共振氢谱和变浓度核磁共振氢谱分析了羰基(CO)与氨基(H—N)之间形成氢键的形式。结果表明,本文举例中联酰胺基团中的CO与H—N以分子间氢键形式存在。

In order to understand the hydrogen-bonding motif with 1H NMR, a hydrazide derivative was taken as example in this article to study hydrogen bond forms between the carbony] （C =O ） and amino （H--N） groups by concentrations dependent 1H NMR spectroscopic experiments and temperature dependent 1 H NMB spectroscopic experiments. The results showed that the protons of both NH-1 and NH-2 in hydrazide group are involved in intermolecular hydrogen bonding with C =O groups. Keywords NMR, Intermolecular hydrogen bond, Intramolecular hydrogen bond, Chemical shift