重症支原体肺炎患儿血清CRP与心肌损伤的相关性研究

Correlation between C-reactive protein and myocardial injury in children with severe mycoplasmal pneumonia

目的:研究重症支原体肺炎患儿血清C反应蛋白(CRP)与心肌损伤的关系。方法:随机选择住院治疗的重症支原体肺炎患儿71例为病例组,同时选取健康儿童36例作为对照组,检测病例组入院治疗前及治疗后3、7、15d和对照组血清CRP及肌酸激酶同工酶(CK-MB)、肌钙蛋白I(CTnI)的浓度。结果:病例组患儿血清CRP及CK-MB、CTnI浓度均明显高于对照组,差异有统计学意义(P均<0.05);病例组患儿血清CRP与CK-MB、CTnI浓度随着治疗时间的延长而降低,不同时间点的差异均有统计学意义(P<0.05);相关性分析表明:血清CRP与CK-MB、CTnI水平呈正相关(r分别为0.697、0.739,P均<0.05)。结论:重症支原体肺炎患儿均有不同程度的心肌损害,CRP的血清浓度可以反映出心肌损害的程度。

Objective; To explore the correlation between C-reactiveprotein（CRP）and myocardial injury in children with severe mycoplasmal pneumonia. Methods. A total of 71 ehildren diagnosed as severe mycoplasmal pneumonia were enrolled as case group and 36 healthy children were assigned as control group,serum creatine kinase isoenzyme（CK-MB）, cardiac troponin I（cTnI） and CRP levels were simulta- neously measured in case group before treatment and 3rd, 7th and 15th days of treatment and the control group. Results=The levels of CK-MB, cTnI and CRP in case group was significant higher than that in the control group （P all〈0.05）. Serum CK-MB, cTnI and CRP levels significantly reduced as length of treatment showing significant difference among different time points （P（0.05）. Correlation analysis indicated that there is positive correlation between serum CRP and CK-MB （r=-0. 697, P〈0. 05） CRP and cT- nI （r=0. 739, P（0.05）. Conclusions：Myocardial injury presents with different severity in children with severe mycoplasmal pneumonia, and serum CRP level can be a indicator of the severity.