血清同型半胱氨酸对高血压早期肾损伤的诊断价值

Value of serum homocysteine in the diagnosis of early renal damage resulted from hypertension

目的:探讨血清HCY水平与高血压及高血压早期肾损伤的关系。方法:根据尿mALB及β2-微球蛋白(β2-MG)的含量将高血压患者分为两组,同时检测血清HCY、BUN、CR及UA的水平。结果:高血压患者血清HCY水平较健康对照组明显升高(P<0.01),高血压早期肾损伤患者血清HCY水平较高血压非肾病患者明显升高(P<0.01);血清HCY与尿mALB及β2-MG呈正相关关系,血清HCY随着尿mALB及β2-MG含量的增多而相应增加。结论:血清HCY的检测可以提高高血压早期肾损伤的检出率。

Objective： To explore the relationship between serum HCY levels and hypertension and early renal injury in hypertention. Methods： Hypertension patients were divided into two groups according to urine mALB and β2-microgiobulin （β2-MG） content, and level of serum HCY, BUN, CR and UA were detected in these patients. Results： Serum HCY levels was significantly increased in patients with early re- nal injury than those without the injury （P（0.01）, serum HCY level was positively correlated with the u- rine mALB and β2-MG. Conclusion： Detection of serum HCY can improve the accuracy of diagnosing early renal injury in hypertension patients.