喹硫平与氯丙嗪治疗癔症性(分离性)精神障碍对照分析

Comparison of quetiapine and chlorpromazine in the treatment of hysterical(dissociative) mental disorders

目的:研究喹硫平和氯丙嗪治疗癔症性(分离性)精神障碍的有效性和安全性。方法:60例癔症性(分离性)精神障碍患者分别应用喹硫平(30例)与氯丙嗪(30例)进行治疗,两组平均剂量为250mg/d,采用简明精神病量表(BPRS)、副反应量表(TESS)评定疗效及副反应。结果:喹硫平与氯丙嗪疗效相似,两组各阶段BPRS评分差异无统计学意义(P>0.05);治疗第8周末,喹硫平组TESS评分较氯丙嗪组明显降低(P<0.01),副反应较氯丙嗪组少且轻。结论:喹硫平与氯丙嗪对癔症性(分离性)精神障碍均有较好的疗效,前者副反应较轻易被接受。

Objective： To investigate the efficacy and safety of quetiapine and chlorpromazine in treatment of hysterical （dissociative） mental disorders. Methods： Sixty cases of hysterical （dissociative） mental disorders were randomly assigned to take quetiapine （n=30） and chlorpromazine （n= 30） at a mean dose of 250 mg/d. Brief psychiatric rating scale （BPRS） and treatment emergent symptoms scale （TESS） were applied to evaluate the efficacy and side effects. Results： The efficacy of chlorpromazine and quetiapine was similar showing no significant difference in BPRS score （P〉0.05） ; however, TESS score significantly decreased and side effects were less in patients taken quetiapine comparing with those taken chlorpromazine. Conclusions.Both quetiapine and chlorpromazine show good effects on the hysterical （dissociative） mental disorders, but side effects of the former was lighter.