2008-2010年鲍氏不动杆菌的临床分布及耐药趋势分析

Clinical distribution and drug resistance of Acinetobacter baumanniifrom 2008 to 2010

目的对2008-2010年临床分离鲍氏不动杆菌的分布特征及耐药性变化趋势进行分析,为临床治疗和预防提供参考。方法检测医院2008年1月-2010年12月住院患者感染的鲍氏不动杆菌,细菌培养分离按《全国临床检验操作规程》(第3版)进行,药敏试验采用MIC法。结果 2008-2010年共检出病原菌208株,分别占19.7%、31.3%、49%,鲍氏不动杆菌对亚胺培南、磷霉素、左氧氟沙星、哌拉西林/他唑巴坦的耐药率分布为18.8%、30.8%、58.7%、69.7%。结论医院获得性鲍氏不动杆菌感染呈增加趋势,各科间分布差异较大,耐药率较高且有多药耐药,应重视该菌感染及耐药监测,预防医院感染发生。

OBJECTIVE To analyze the distribution and drug resistance of Acinetobacter baumannii from 2008 to 2010 so as to provide reference for clinical treatment and prevention.METHODS A.baumannii isolates causing nosocomial infection in hospitalized patients from 2008 to 2010 were detected,the bacterial culture and isolation were performed according to the National Clinical Laboratory Procedures（3rd edition）,the drug susceptibility testing was performed with MIC method.RESULTS There were totally 208 strains of pathogens isolated from 2008 to 2010,accounting for 19.7%,31.3%,and 49%,respectively,the drug resistance rates of A.baumannii to imipenem,fosfomycin,levofloxacin,and piperacillin/tazobatam were 18.8%,30.8%,58.7%,and 69.7%,respectively.CONCLUSION The hospital-acquired A.baumannii infections are increased and significantly different among various departments,the drug resistance rate is high and multidrug-resistant;attention should be paid to A.baumannii infections and the surveillance of drug resistance so as to prevent nosocomial infections.