2008-2010年肿瘤中心医院感染病原体分布特点及耐药性分析

Distribution and drug resistance of pathogens causing nosocomial infections in cancer center from 2008 to 2010

目的分析肿瘤患者医院感染的病原体分布特点及耐药性。方法回顾性调查分析2008年1月-2010年12月中山大学肿瘤防治中心医院感染相关资料。结果 755例发生医院感染的患者中共送检1183份标本,检出1093株病原体,检出率为92.39%,其中革兰阴性菌472株占43.19%,主要为大肠埃希菌;真菌336株占30.74%,主要为白色假丝酵母菌;革兰阳性菌281株占25.71%,主要为葡萄球菌属;此外检出带状疱疹病毒及支原体属各两株;革兰阳性菌及革兰阴性菌的耐药率均较高,检出1株耐万古霉素屎肠球菌,真菌对抗真菌药物普遍敏感。结论肿瘤中心引起医院感染的病原体以革兰阴性菌为主,部分细菌对抗菌药物的耐药情况已较严重。

OBJECTIVE To investigate the distribution and drug resistance of pathogens causing nosocomial infections in the tumor patients.METHODS A retrospective survey was conducted to analyze the correlated data of the patients with nosocomial infections in Cancer Center of Sun Yat-sen University from Jan 2008 to Dec 2010.RESULTS Among 755 patients with nosocomial infections,there were totally 1183 specimens submitted,from which 1093 strains of pathogens were isolated with the detection rate of 92.39%,there were 472(43.19%) strains of gram-negative bacteria among which Escherichia coli was dominated,there were 336(30.74%) strains of fungi among which Candida albicans was dominated,and there were 281(25.71%) strains of gram-positive bacteria among which Staphylococci were dominated,in addition,there were 2 strains of herpes zoster viruses and 2 strains of Mycoplasma isolated;the drug resistance rates of both gram-positive bacteria and gram-negative bacteria were relatively high,with 1 strain of vancomycin-resistant Enterococcus faecium being found,and fungi were widely susceptble to the antifungal drugs.CONCLUSION Gram-negative bacteria are the predominant pathogens causing nosocomial infections in the cancer center,and some of the pathogens have produced serious drug resistance to the antibiotics.