基于中药活性小分子单克隆抗体的复方配伍机理研究新思路

A New Thought of Compound Compatibility Mechanism Based on Active Small Molecules Monoclonal Antibodies in Herbs

中药复方配伍机理研究一直是中医药研究的重点内容之一,但复方的复杂性使得目前研究方法难以适合其自身特点,制约了中医药现代化、国际化进程。笔者提出药物配伍关系与其体内代谢过程密切相关,制备中药活性小分子单克隆抗体,利用免疫分析方法能够实现多种主要药效成分的同时检测,可以阐明中药的体内代谢及相互作用关系,是进行复方配伍机理研究的新思路。

Compatibility mechanism study of Chinese herbal compound （CHC） has been one of key con- tents in Chinese medical research, but the present research methods are not suitable for its own features due to its complexity, which has restricted the process of modernization and internationalization of Chinese medicine. In this paper, we addressed that the compatibility is closely correlated to their in vivo metabolic processes. The preparation of active small molecules monoclonal antibodies in herbs and testing a variety of effective composi- tions simultaneously using immunoassay can clarify the in vivo metabolism and mutual interactions of Chinese herbs, which is a new thought of studying the compound compatibility mechanisms.