血瘀证分子调控网络研究历程及前瞻

The Research Course and the Perspective of Molecular Regulation Network and Blood Stasis Syndrome

梳理血瘀证科学研究文献,对血瘀证分子调控网络研究历程及前瞻进行简要述评。血瘀证本质研究最早由陈可冀、王阶等首次提出,随后历经30余年,研究逐渐深入。血瘀证研究历程主要包括血瘀证诊断标准的制定,血瘀证动物模型的建立,家系、双生子与临床流行病学相结合的血瘀证研究,四大组学与血瘀证分子调控网络研究,以及信号转导网络与血瘀证研究等。随着新一代高通量测序技术在基础研究、临床诊断和药物研发等领域的运用,可看到人类疾病全基因网络研究的希望,如代谢性疾病、癌症等。这些重大研究成果,为血瘀证深层次本质研究提供了新思路。

Studying the literature of blood stasis syndrome （BSS）, we reviewed the research course and the perspective of molecular regulation network and BSS. The essence study of BSS was firstly proposed by CHEN Ke-ji and WANG Jie, and developed for more than thirty years. The course for BSS study mainly included the formulation of BSS diagnostic standard, the establishment of BSS animal model, pedigree methods, twins combined clinical epidemiological survey of BSS research, the four ＂zu＂ subjects combined molecular regulation network of BSS, signal transduction system network and BSS research, and so on. Along with a new sequencing approach in basic research, clinical diagnostics, and drug development, we are promising to see the whole gene network research of human diseases, such as metabolic disease, cancer, and etc. These achievements could provide a new way of thinking for further studying the essence of BSS.