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顺铂肾毒性的药物基因组学研究进展 被引量:4

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摘要 目的:综述近年来顺铂肾毒性的药物基因组学研究进展。方法:查询国内外有关文献,并进行归纳与总结。结果:顺铂肾毒性存在的个体性差异与细胞内顺铂的蓄积增多、细胞生物转化能力和DNA修复能力减弱3种过程中的药物代谢基因遗传变异密切相关。结论:随着药物基因组学研究的不断深入,顺铂将会实现真正意义上的个体化用药。
出处 《中国医院药学杂志》 CAS CSCD 北大核心 2012年第19期1569-1571,共3页 Chinese Journal of Hospital Pharmacy
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