干细胞移植治疗心力衰竭的临床研究进展

Stem cell transplantation for treatment of heart failure

近年来,药物、器械和外科手术治疗心力衰竭的进展相对滞缓,干细胞移植治疗逐步成为这一领域新的热点。目前的临床研究对干细胞移植治疗心力衰竭的疗效尚无定论。随着大规模、随机、双盲、安慰剂对照、多中心临床试验的进一步开展和移植策略的优化,干细胞移植将可能成为治疗心力衰竭极富前景的新手段。

Summary Recently, slow progress was attained in the field of the treatment for heart failure by drugs, device and surgery. However, significant strides have been made by investigators in the study of stem cell therapy for heart failure. Thus far, the efficacy of stern cell therapy for the treatment of heart failure in clinical trials remains controversial. Larger randomized, double-blind, placebo-controlled, multicenter trials were warranted to be performed to improve the efficacy and safety, while the therapeutic strategy of stem cell transplantation holds great promise for the treatment of heart failure.