PTTG和MMP-9蛋白表达在食管癌临床分期中的价值

Value of Protein Expression PTTG and MMP-9 with Clinical Stage of Esophageal Carcinoma

目的研究PTTG和MMP-9在食管癌中的表达及其相关性,探讨它们对食管癌临床分期的价值。方法应用免疫组织化学SP法检测84例食管癌组织中PTTG和MMP-9蛋白表达,结合临床病理参数并将其纳入食管癌临床分期进行预后分析。结果 PTTG和MMP-9在食管癌组织中均呈阳性表达,且两者表达呈正相关。PTTG、MMP-9蛋白在食管癌临床分期较晚的患者中阳性表达率明显高于临床分期早的患者。结论 PTTG和MMP-9蛋白在食管癌组织中呈高表达,且与食管癌临床分期显著正相关,提示两者在食管癌发生、发展及侵袭转移过程中可能起重要作用。

Objective To explore the function of PTTG and MMP-9 protein expression and evaluate their relationship with clinical stage of esophageal carcinoma. Methods Immunohistochemistry SP was used to check the protein expression of PTTG and MMP-9 in biopsy tissue specimen of 84 cases esophageal carcinoma, and the relationship between protein expression level and clinical stage grades was analyzed. Results PTTG and MMP-9 protein were high expression and with positive correlation in esophageal carcinoma. Positive expression rate were higher in late clinical stage than that in early stage in esophageal carcinoma. Conclusion PTTG and MMP-9 are high expression,and the two sorts of protein expression have a positive correlation with clinical stage of esophageal carcinoma. It suggests that PTTG and MMP-9 genes play an important role in regulating occurre,development,invasion and metastasis of esophageal carcinoma.