用于荧光断层成像的边缘反投影三维表面轮廓提取算法

A 3D Edge Back Projection Based Surface Extraction Method Used in Fluorescence Tomography

目的为非接触式荧光分子断层成像提供一种快速、准确、简单易行的三维表面轮廓提取方法。方法在获得了成像物体的多角度白光图像后,首先用水平集方法提取边界,然后用基于边缘的反投影方法获得断层图像,最后通过提取每一断层图像的轮廓而最终获得成像物体的三维表面轮廓数据。结果仿体实验和小动物实验表明该方法与以往所采用的基于滤波反投影的表面轮廓提取方法具有相当的精度,提取速度则加快了1～25倍。结论该方法简单易行,能够适用于荧光分子断层成像系统,并能快速、准确地为后续断层重建提供所需的三维表面轮廓。

Objective To provide a fast, accurate and easy-to-implement three-dimensional（3D） surface ex- traction method for noncontact fluorescence molecular imaging tomography. Methods After capturing the white-light images at different projection angles by a charge coupled device （CCD） , the edges of the image ob- ject were detected using level set method. Then the slice images were generated using edge based back projec- tion method. Finally, the 3D surface of the image object was obtained by extracting the outline of each slice image. Results Phantom and small animal experiments demonstrated that the proposed method significantly ac- celerated surface extraction by 1 N 25 times as compared with the filtered back projection based surface extrac- tion method used previously while keeping similar accuracy. Conclusion The proposed method can be applied to the imaging system easily and be used to obtain the required 3D surface fast and accurately for the following reconstruction.