重要自身免疫性疾病的发病机制及其免疫干预策略

Autoimmune diseases:immuno-pathogenic dissection and strategy exploration for immune intervention

自身免疫病是由于机体免疫系统对自身组织和器官发生了免疫应答并造成组织损伤和功能障碍的一类疾病。在"211工程"三期建设中,上海市免疫学研究所和上海市风湿病学研究所的研究团队以免疫调节与免疫病理为主题,围绕系统性红斑狼疮、类风湿性关节炎和银屑病等3大疾病的发病机制和免疫调节开展深入研究,发展免疫干预新靶点与新策略,为上述疾病的防治和诊断提供重要的新策略。系统性红斑狼疮的发病机制及临床治疗技术研究项目获国家科学技术进步奖二等奖。

Autoimmune diseases arise from inappropriate immune responses against molecules and organs normally present in the body, resulting in tissue damage and functional defects. Supported by ＂211 Project＂, the research groups from Shanghai Institute of Immunology and Shanghai Institute of Rheumatology have been working cooperatively to explore the immuno-regulation and immuno-pathogenesis of important autoimmune disorders including systemic lupus erythematosus （SLE）, rheumatoid arthritis （RA） and psoriasis （PS）, in which facilitate the diagnosis and intervention of the diseases. One of the research achievements, the pathogenesis of SLE and its novel therapeutic strategy, was awarded the second prize of 2009 National Science and Technology Progress Award.