帕金森病发病机制与诊治的基础与临床研究进展

Basic and clinical research on the pathogenesis,diagnosis and treatment of Parkinson's disease

帕金森病(PD)是中老年常见的神经系统变性疾病,由于其具有高患病率、高致残率和慢性病程的特点,对PD早期诊断、治疗及预防的研究已成为各国相关领域科学家共同关注的热点和焦点。课题组利用前期工作建立起来的PD临床资源库和应用基础研究平台,着眼于转化医学,紧紧围绕PD的发病机制和临床治疗开展研究工作,研究成果的主要创新发现:①PD患者血清IgG及C5a可诱导小胶质细胞活化并对多巴胺(DA)能神经元产生损伤作用,首次探讨了突触共核蛋白在DA能神经元内的转运与小胶质细胞持续激活有关;②中药单体姜黄素、红景天甙、雷公藤TW397对PD细胞和动物模型具有保护与治疗作用;③转染Neurturin或IL-10的C17.2神经干细胞和转染Neurturin的骨髓基质干细胞对PD大鼠模型具有保护与治疗作用;④报道了我国PD患者的疾病经济负担及药物经济学现况,主持制定我国第一、二部《中国帕金森病治疗指南》,主编了《帕金森病》系列专著,为进一步合理、规范我国的PD治疗起到了重要的指导和推动作用。研究成果获得2010年教育部自然科学奖一等奖。

Parkinson＇s disease （PD） is one of the most common neurodegenerative diseases, Because of high prevalence, severe disability and chronic course of disease, it becomes one of research focus in modern medicine from diagnosis to treatment and prevention. Based on our previous studies, we further extended our investigation into the field of pathogenesis, diagnosis and treatment in PD with characteristics of translational medicine. We found that： ①Serum IgG and C5a from PD patients could activate the microglia and produce the damage effects in turn; and lysosome enzyme released by early microglia activation was harmful for the dopaminergic neurons; ②Three kinds of traditional Chinese herbal medicine-- curcumin, salidroside and tripchlorolide （TW397） had neuroprotective and therapeutic effects in cellular and animal models of PD; ③Two types of neuron stem cells （c17.2 neuron stem cell transfected with neurturin or IL-10, or bone marrow stem cell transfected with neurturin） were proved exerting neuroprotective and therapeutic effects in rat models of PD; ④We investigated the economic burden of PD in China and provided the first data of the current pharmacoeconomics situation in Chinese PD patients. Furthermore, we presided the first and second version ＂Chinese guidelines for the treatment of Parkinson＇s disease＂, which intended to standardize the clinical treatment of PD in China. The research achievement won the first prize of Natural Science Award of Ministry of Education in 2010.