金黄色葡萄球菌L-型毒素休克综合征——1例研究报告与文献复习

Toxic shock syndrome caused by staphylococcus aureus: studies on a fatal case and review of literatures

毒素休克综合征(Toxic Shock Syndrome,TSS)是近年来报导的一个新的临床征候群,国内迄今报告极少。本文报导一例金黄色葡萄球菌(简称金葡菌)变异形态——L-型菌引起的TSS。其临床表现和实验室检查结果,尤其是微生物学研究结果,基本符合美国疾病控制中心(CDC)制定的有关诊断标准。另外,本文讨论了有关诊断与鉴别诊断,发病机理及L-型菌的致病作用,并综述了该病近年来的主要研究进展。

Toxic shock syndrome (TSS) is, relatively, a new disorder recently recognized by medical circle. So far, very few cases have been reported in our country. This paper presents a male fatal case, of whom, the clinical manifestations and laboratory findings basically coincided with the diagnostic criteria set by the CDC of USA. What is special of all is that cell-wall-deficient variant of staphylococcus aureus-L-form bacteria wereisolated from the patient's blood, and the re(?) vertants of which were proved to be a TSS toxin-1 (TSST-1) positive strain. Some other aspects, such as the differencial diagnosis, pathogenesis and the possible role of L-forms, are also discussed, while some major advances in TSS reviewed.