血清胱抑素C联合尿微量白蛋白检测在儿童肾炎诊断中的应用

Application of serum cystatin C combined with urine microalbumin testing in diagnosisfor children nephritis

目的探讨血清胱抑素C（cystatinc）联合尿微量白蛋白（umAlb）检测在儿童肾炎诊断中的应用。方法对我院肾内科住院肾炎患儿和门诊健康体检儿童血清进行CysC、Urea、Cr测定，同时留取全部研究对象的晨尿检测umAlb，采用SPSS12．0统计软件包进行统计分析。结果肾炎患儿组血清CysC、Cr和尿umAlb均值分别为1．24mg／L、70IXmol／L和129．23mg／L，均显著高于健康对照组，差异有统计学意义（P〈0．01）各种肾炎患儿血清CysC和尿umAlb的阳性检出率分别为60％和56％，高于Urea的22％和Cr的36％，差异有统计学意义（P〈0．01）。结论血清CysCn可作为儿童肾炎诊断中一项敏感指标，联合尿umAlb检测可提高小儿。肾炎早期肾功能损害的检出率。

Objective To study the application of serum cystatin C combined with urine microalbumin testing in diagnosis for children nephritis. Methods Patients in the department of neph- rology and physical health children were enrolled in our study. In all subjects, serum cystatin C, urea, ceatinine and urine microalbumin were measured and all analysis were performed by SPSS 12.0 software. Results The average levels of serum cystatin C, ceatinine and urine microalbumin in nephritis children were 1.24 mg/L, 70 μ mol/L and 129.23 mg/L respectively, which were significantly higher than those in control group（P〈 0.01）; the positive detectable rate of serum cystatin C and urine microalbumin were 60% and 56% in various nephritis, higher than the urea （22%） and ceatinine （36%）.Conclusion Serum cystatin C can be a diagnostic indicator of nephritis in children, if combined with urine microalbumin detection it can increase the recognization rate of early renal lesion.