运动疗法防治膝关节骨性关节炎的临床研究

Clinical study of exercise therapy in the treatment of knee osteoarthritis

目的观察运动疗法对膝关节骨性关节炎的临床疗效。方法随机将200例膝关节骨性关节炎患者分为运动疗法组和消炎镇痛药对照组。最终进入统计分析的运动疗法组90例,消炎镇痛药对照组81例,脱落29例。在初诊时和治疗8周后,以JKOM、WOMAC评分结果等评判并比较分析治疗效果。结果两组治疗干预前后的两项评分均有改善,其中JKOM评分的改善率,运动疗法组比消炎镇痛药组更高(P=0.038,中央值的95%可信区间0.008～0.248),而WOMAC评分的改善率,两组间比较无统计学意义(P=0.102,中央值的95%可信区间-0.026～0.272)。结论运动疗法对于膝关节骨性关节炎有良好的近期效果。

Objective To observe the clinical effects of exercise therapy in knee osteoarthritis. Methods Using a randomized open label trial, 200 cases were divided into exercise therapy group, and control group of non steroidal anti- inflammatory drugs. The final complete information into the statistical score of 171 cases,29 cases off. 90 cases were in SLR group and 81 cases were in NSAID group. In newly diagnosed and 8 weeks later, Japanese Knee Osteoarthritis Measure and Western Ontario and McMaster University Osteoarthritis Index were evaluation, and a comparative analysis of the results of two groups. Results In the two groups before and after the intervention of JKOM, WOMAC score were statistically significant improvements, including JKOM improvement rate, exercise therapy group than NSAID group was higher （P=0.038, 95% CI 0.008-0.248）, and the rate of improvement in WOMAC, compared between the two groups was not statistically significant （P=0.102, 95%CI -0.026-0.272）. Conclusion Exercise therapy for knee osteoarthritis has good short-term effect, including pain relief effects,and the activity of daily living is better than drug therapy.