阿立哌唑与利培酮治疗老年期精神分裂症对照研究

A control study of aripiprazole and risperidone on the treatment of senile schizophrenia

目的评价阿立哌唑治疗老年期精神分裂症的有效性和安全性。方法将56例老年期精神分裂症患者随机分配到阿立哌唑组28例和利培酮组28例,进行为期6周的对照研究。采用阳性和阴性症状量表,临床疗效总评量表、治疗中出现的症状量表评定疗效和安全性。结果治疗6周两组PANSS评分较治疗前均显著降低(均P<0.05),各时点PANSS评分两组间减分差异无统计学意义。治疗6周末,阿立哌唑组显效率61.5%,利培酮显效率72%,两组比较差异无统计学意义(x2=0.16,P>0.05)。两组均未发生严重相关不良事件。阿立哌唑引起震颤及静坐不能为少。结论阿立哌唑与利培酮治疗老年精神分裂症的疗效显著且相当,但阿立哌唑安全性、依从性更好,更适合老年期精神分裂症的治疗。

Objective To assess the efficacy of aripiprazole on the treatment of senile schizophrenia. Methods A randomized,doubl-blind,double-dummy,comparative study was performed with a cours of 6 weeks.Fifty-six patients with schizophrenia were randomized into aripiprazole group （n=28） and risperidone group （n--28）.The positive and negative syndrome scale, clinical global impression, treatment emergent symptom scale were used to assess the effectiveness and the safety of the treatment. Results By the end of the 6 week treatment,in both groups,the scores of PANSS decreased significantly comparing to the baseline（P 〈 0.05） without statistically different between two groups. By the end of 6 week, total clinical effective rates were 61.5% in aripiprazole group and 72% in brisperidone group,without any statistically significant difference beween the two groups（X^2=0.16, P 〉 0.05）. No severe adverse events were reported in both groups, However, the tremor and akathisia in aripiprazole group was much lower than in risperidone group. Conclusion Both aripiprazole and risperidone are effective in the treatment of senile schizophrenia, but aripiprazole has better safety and compliance and is more suitable for senile schizophrenia.