下呼吸道感染鲍曼不动杆菌的耐药性监测

Drugresistance of Acinetobacter baumanii in lower respiratory tract infection

目的探讨下呼吸道感染中鲍曼不动杆菌的耐药情况,为临床抗感染治疗提供科学依据。方法对2010年临床下呼吸道感染分离的104株鲍曼不动杆菌耐药情况进行回顾分析,用K-B法进行体外药敏试验。结果 104株鲍曼不动杆菌药敏试验结果显示该菌对多黏菌素耐药率最低,为7.7%,其次是美罗培南(21.2%)、亚胺培南(24.0%)、头孢哌酮/舒巴坦(28.8%),对其他抗生素均有较高的耐药性。结论鲍曼不动杆菌是下呼吸道感染常见病原菌,多重耐药性严重,临床应根据药敏结果合理用药,以便有效控制感染和减缓耐药菌株的产生。

Objective To study the drug resistance of Acinetobacter baumanii in lower respiratory tract infection, and to provide reference for the clinical resisting infection. Methods Drug susceptibility results of 104 strains of Acinetobacter baumanii separated from the lower respiratory tract infection in 2010 were analyzed retrospectively and K-B method was applied for the drug susceptibility test. Results The antibiotic susceptibility test in vitro showed： the resistant rate of Acinetobacter baumanii to polymyxin was lowest（7.7%）, followed by meropenem（21.2%）,imipenem（24.0%）,cefoperazone/ sulbactam（28.8%）. Acinetobacter baumanii had higher resistance rates to the other antibaeterials. Conclusion Resistance of Acinetobacter baumanii is quite serious.Clinician should base on drug susceptibility test to choose antibiotics reasonably and controlling the infection effectually and delaying the occurrence of bacteria resistance.