舒肝解郁胶囊与帕罗西汀治疗抑郁症的对照研究

A comparative study of Shugan-jieyu capsule and Paroxetine in the treatment of depression

目的:了解舒肝解郁胶囊对轻中度抑郁症的治疗效果及不良反应。方法:将符合CCMD-3轻中度抑郁症诊断标准的60例患者随机分为舒肝解郁组(30例)和帕罗西汀组(30例),分别在治疗前以及治疗后的第l、2、4、6周采用汉密尔顿抑郁量表(HAMD)评定疗效,采用副反应量表(TESS)评定不良反应。结果:舒肝解郁胶囊和帕罗西汀对于轻中度抑郁症均有显著疗效,2组间疗效无显著差异(P>0.05)。舒肝解郁组的不良反应明显小于帕罗西汀组(P<0.05)。结论:舒肝解郁胶囊治疗轻中度抑郁症安全有效,不良反应小。

Objective：To evaluate the therapeutic effect and side effects of Shugan -jieyu capsule for treating the patients with depression. Methods ： A total of 60 patients meeting the criteria of CCMD - 3 for mild to moderate depression were randomly assigned to Shugan -jieyu capsule group （n = 30） or Paroxetine group （n = 30） for 6 weeks before and after treatments of 1,2,4,6 weeks. The efficacy and side effects were assessed with HAMD and TESS. Results： Both Shugan -jieyu capsule group and Paroxetine group showed significant improvement after treatment, while there was no significant difference between two groups. Shugan - jieyu capsule group had significantly less side effects than Paroxetine group. Conclusions： Shugan -jieyn capsule is safe and effective with slight side effects for treating patients with depression.