α-硫辛酸、前列腺素E1、甲钴胺治疗糖尿病周围神经病变的临床观察

Clinical study of α-lipoic acid,prostaglandinE1 & methylcobalamin in the treatment of diabetic neuropathy

目的:评价α-硫辛酸联合前列腺素E1、甲钴胺治疗糖尿病周围神经病变的疗效及安全性。方法:选择90例2型糖尿病周围神经病变(DPN)患者,随机分成三组。对照组1:弥可保500μg静注、联合前列腺素E1 100μg静滴,每日1次;对照组2:弥可保500μg静注、联合α-硫辛酸300μg静滴,每日1次;治疗组联合给予上述3种药物,连续2周观察疗效。结果:症状改善率3组比较,治疗组优于对照组,P<0.05;两对照组间比较无明显差异。神经传导速度(NCV)改善率比较,治疗组优于对照组,P<0.05;两对照组间比较无明显差异。结论:α-硫酸锌联合前列腺素E1、甲钴胺可以明显提高DPN患者的MCV,改善症状。疗效优于仅使用甲钴胺和前列腺素E1或甲钴胺和α-硫辛酸。临床上可以多种药物联合使用治疗DPN。

Objective ：To evaluate the effect of α-lipoic acid （ALA）, prostaglandinE1, methylcobalamin on diabetic periph eral meuropathy （DPN）. Methods：90 type2 diabetic patients complicated with DPN were randomly divided into 3 groups： control groupl （n = 30）, receiving methylcobalamin 500ug at the infection and prostaglandinE1 100ug given by intravenous drip infusion once a day for 14 days; control group2 （n = 30） , administered with methyleobalamin 500ug at the infection and ALA 300ug by intravenous drip infusion once a day for 14 days; treatment group （n = 30）, receiving 3 kinds of medicine. As indicated Above：methylcobalamin, prostaglandinE1, ALA ,for 14 days. Results： On the improvement of symptom, the TSS of the treatment groups lower , compared with the control group （ P 〈 0.05 ）. The NCV of the treatment group was higher than the control group （ P 〈 0.05 ）. There are no significant differences between the two control groups. Conclusions： ALA combined with prostaglandinE1, methyleobalamin effectively improves the sensitive symptoms of DPN patients and increase s in NCV ; Variety of drugs of the united usage is safe for most of DPN patients . Curative effect of the united usage is superior to only use two kind of drugs.