P38-一种信号分子在神经系统疾病中的作用(英文)

Role of P38,a Kind of Signaling Molecules in CNS Diseases

因P38对凋亡的作用,对P38信号分子及其相关信号通路的研究已成为目前医学科学界注目的焦点.对P38的基本概念,生物学功能及其对神经系统疾病的作用等进行综述.另外,与P38相关的信号通路也将在本文进行探讨.对P38及其相关通路的研究将有助于不同系统多种疾病的治疗新药的发现,最终给一些医学难治性疾病,包括脊髓损伤和阿尔兹海默病等的治疗带来新的曙光.

Currently,the researches of P38 and related signaling pathway have become a hotspot in various filed in medical science,due to its role in apoptosis.This review discussed the basic concept,biological function of P38 signaling pathway and its effect on the Central Nervous System（CNS） diseases.Moreover,the related signaling pathways of P38 were also explored.The researches for P38 and its related signaling pathway will contribute to the discovery of new drugs in various diseases in different system,ultimately shed a new light on some incurable diseases,including spinal cord injury（SC）I and Alzheimer’s disease（AD）.