十二指肠癌及溃疡组织幽门螺杆菌感染对比

Comparison of Helicobacter pylori infection between duodenum carcinoma and ulcer

目的研究幽门螺杆菌(Helicobacter pylori,Hp)在十二指肠溃疡及十二指肠癌中的表达及意义。方法采用免疫组织化学染色方法检测40例十二指肠溃疡组织(对照组)和32例十二指肠癌组织(观察组)中Hp表达情况。结果对照组Hp阳性表达率(72.5%)与观察组(12.5%)差异显著(P<0.005)。结论 Hp感染在十二指肠溃疡发生发展中起着重要作用,而与十二指肠癌发生关系不大。

Objective To investigate the expression and significance of Helicobacter pylori （Hp） in human duodenum carcinoma and ulcer. Methods The expression of Hp in 40 specimens of duodenal ulcer tissue （ control group）, 32 specimens of duodenum carcinoma tissue （ observation group） was determined by immunohistochemistry, Results The expression of Hp in control group （72. 5% ） was signifi- cantly higher than that （ 12. 5% ） in observation group （P 〈 0. 005 ）. Conclusions Hp infection may play an important role in the develop- ment of duodenal ulcer, not be relevant to the development of duodenum carcinoma.