参脉注射液对不稳定型心绞痛的治疗作用及其对组织因子途径抑制物2的影响

The Efficacy of ShenMai Injection on Unstable Angina and Its Effect on Tissue Factor Pathway Inhibitor-2

目的研究参麦注射液对不稳定型心绞痛治疗疗效并了解其机制。方法入选178例不稳定型心绞痛患者,分为治疗组和对照组,治疗组为常规西药治疗基础上加用参麦注射液,对照组常规西药治疗加极化液注射注射。观察心绞痛症状及心电图缓解情况,并检测治疗前后患者血浆组织因子途径抑制物2的浓度。结果治疗组及对照组基线情况基本相同。治疗组及对照组症状缓解率分别为84.3%和69.7%,心电图好转率分别为74.5%和61.8%,两者比较均差异具有显著(P<0.05)。治疗前后患者血浆组织因子途径抑制物2均有下降,但前后差值治疗组下降明显,两者比较差异具有显著性(P<0.01)。结论在常规西药治疗基础上加用参麦注射液可有效缓解不稳定型心绞痛的发作,参脉注射液对不稳定型心绞痛的治疗作用可能与不稳定型心绞痛患者血浆组织因子途径抑制物2水平变化相关。

Aim To study clinical effects of Shenmai injection on unstable angina and understand its mecha- nism. Methods 178 cases with unstable angina, was divided into treatment group and control group. Treatment group was treated by conventional western medicine plus ShenMai injection. The control group was treated by conventional western medicine plus GIK injection. Observe symptoms of angina and ECG remission situation and detect the plasma tis- sue factor pathway inhibitor-2 concentration before and after treatment. Results The clinical baseline was similar. Symptom remission rates of treatment group and control group were 84. 3%, 69. 7% ;ECG improvement rates was 74. 5%, 61.8%. There were significant differences （ P 〈 0.05 ）. The plasma tissue factor pathway inhibitor-2 declined after treatment. But the treatment group decreased more significantly; the difference was significant （P 〈 0. 01 ）. Conclu- sions The Shenmai injection plus the conventional western medicine can effectively alleviate the unstable angina. Its treatment effect may be related to the changes of tissue factor pathway inhibitor-2.