同型半胱氨酸联合踝臂指数及C反应蛋白在下肢外周动脉疾病患者中的临床意义

The Clinical Significance of Homocysteine Combined with Ankle Brachial Index and C-Reactive Protein in Patients with Peripheral Arterial Disease

目的探讨血浆同型半胱氨酸联合踝臂指数及C反应蛋白对评估下肢外周动脉疾病病变程度的临床应用价值。方法测定经选择性下肢动脉造影证实为下肢外周动脉疾病(PAD)患者(n=86)及正常对照组(n=80)的血浆同型半胱氨酸(Hcy)、C反应蛋白(CRP)浓度及踝臂指数(ABI),分析Hcy、CRP及ABI与下肢动脉病变之间的关系。结果 PAD组血浆Hcy及CRP均明显高于正常对照组(P<0.05和P<0.01),ABI明显低于正常对照组(P<0.01)。PAD组中多支病变组血浆Hcy及CRP均高于单支病变组(P<0.01和P<0.05),ABI低于单支病变组(P<0.01)。结论血浆Hcy、CRP及ABI水平与下肢动脉病变程度相关,对临床病情的评估具有重要指导价值。

Aim To discuss the clinical significance of the plasma levels of homocysteine （Hcy） and C-reactive protein（CRP） combined with ankle brachial index（ABI） to the assessment of the severity of peripheral artery lesions in pa- tients with peripheral arterial disease（PAD）. Methods The plasma levels of Hcy and CRP combined with ABI were test in patients （n = 86 ） with PAD confirmed by selective peripheral angiography, and in the normal control group （n = 80）. Relationship between the severity of peripheral artery lesions with the plasma levels of Hcy and CRP combined with ABI was analysed. Results Compared with the normal control group, the plasma levels of Hcy and CRP in PAD group were significantly higher than those of the normal control group（ P 〈 0. 05 and P 〈 0. 01 ）, and ABI was significantly lower （ P 〈 0. 01 ）. In PAD group, the plasma levels of Hcy and CRP in multi-vessel disease sub-group were significantly higher than in single-vessel disease sub-group（P 〈0. 01 and P 〈0.05）, and ABI was significantly lower（P 〈0. 01 ）. Conclu- sions The plasma levels of Hcy and CRP combined with ABI are related to the severity of peripheral artery lesions, which has the important guiding value to evaluate the clinical condition.