对氧磷酶3基因研究进展

Research Progress of Paraoxonase-3

对氧磷酶3是对氧磷酶基因家族成员之一,除对氧磷酶3外,还包括对氧磷酶1和对氧磷酶2,它们具有大量结构同源性,且所有三个蛋白均能阻止氧化应激和对抗炎症,因此在许多疾病如动脉粥样硬化、肥胖、糖尿病、炎性肠病以及精神疾病中发挥重要作用。体外研究表明,对氧磷酶3的抗氧化能力比对氧磷酶1还要强,因此对氧磷酶3也可能具有成为某些疾病的治疗因子的潜能。本文总结近几年关于对氧磷酶3的一些最新发现,以便为对氧磷酶家族的进一步研究提供新思路。

Paraoxonase-3 （PON3） is a member of the paraoxonase （PON） family. In addition to PON3, it also includes PON1 and PON2. They share a large number of structural homology, and all the three proteins prevent oxidative stress and fight inflammation. They therefore seem central to a wide variety of human illnesses, including atherosclerosis, obesity, diabetes, inflammation bowel disorders and mental disorders. In vitro studies, the antioxidant capacity of PON3 is even stronger than PON1, so PON3 may also have the potential to become the treatment factors of certain diseases. The purpose of this review is to conclude some of the latest findings on PON3 in recent years, so as to provide new ideas for fur- ther research of the PON family.