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日本青鳉2种WNT4基因的克隆及鉴定(英文) 被引量:6

MOLECULAR CLONING AND IDENTIFICATION OF TWO WNT4 GENES FROM THE MEDAKA (ORYZIAS LATIPES)
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摘要 Wingless-type MMTV integration site family,member 4(WNT4) is a critical signaling molecule,regulating cell-cell interactions,proliferation,differentiation,migration,and gene activation [1,2].It is a highly conserved gene with mammals and has multiple roles in organogenesis and homeeostasis,and it has special importance in the sexual differentiation of the ovary [3 - 6]. Wingless-type MMTV integration site family, member 4 (WNT4) is a critical signaling molecule, regulating cell-cell interactions, proliferation, differentiation, migration, and gene activation. It is a highly conserved gene with mammals and has multiple roles in organogenesis and homeeostasis, and it has special importance in the sexual differentiation of the ovaryt3-61. WNT4-mutant females show a lack of mullerian ducts, an increase in ectopically steroidogenic cell migration,
出处 《水生生物学报》 CAS CSCD 北大核心 2012年第5期983-986,共4页 Acta Hydrobiologica Sinica
基金 Project of National Natural Science Foundation of China(Grant No.31072199) the program of Japan Society for the Promotion of Science(JSPS)
关键词 WNT4基因 克隆 系统进化分析 同线性分析 青鳉 WNT4 gene Cloning Phylogenetic analysis Synteny map Medaka
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  • 1Kim Y, Kobayashi A, Sekido R, et al. Fgf9 and WNT4 act as antagonistic signals to regulate mammalian sex determina- tion [J]. PLoS Biology, 2006, 4(6): 1000-1009.
  • 2Yu H, Pask A J, Shaw G, et al. Comparative analysis of the mammalian WNT4 promoter [J]. BMC Genomics, 2009, 10: 416.
  • 3Vainio S, Heikkila M, Kispert A, et al._Female development in mammals is regulated by Wnt-4 signalling [J]. Nature, 1999, 397(6718): 405-409.
  • 4Bernard P, Harley V R. WNT4 action in gonadal develop- ment and sex determination [J]. The International Journal of Biochemistry & Cell Biology, 2007, 39(1): 3-43.
  • 5Wilhelm D, Palmer S, Koopman P. Sex determination and gonadal development in mammals [J]. Physiological Reviews, 2007, 87(1): 1-28.
  • 6Pellegrino M, Maiorino R, Schonauer S. WNT4 signaling in female gonadal development [J]. Endocrine Metabolic & lmmune Disorders- Drug Targets, 2010, 10(2): 168-174.
  • 7Jeays-Ward K, Dandonneau M, Swain A. WNT4 is required for proper male as well asfemale sexual development [J]. Developmental Biology, 2004, 276(2): 431-440.
  • 8Yu H, Pask A J, Shaw G, et al. Differential expression of WNT4 in testicular and ovarian development in a marsupial [J]. BMC Developmental Biology, 2006, 6:44.
  • 9DiNapoli L, Capel B. SRY and the standoff in sex determi- nation [J]. Molecular Endocrinology, 2008, 22(1): 1-9.
  • 10Chue J, Smith C A. Sex determination and sexual differentia- tion in the avian model [J]. FEBS Journal, 2011, 278(7): 1027-1034.

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