光动力抗菌化学疗法治疗甲氧西林耐药金黄色葡萄球菌感染研究进展

Advances in the research of photodynamic antimicrobial chemotherapy for treating methicillin-resistant Staphylococ- cus aureus infection

甲氧西林耐药金黄色葡萄球菌（methicillin—re—sistant Staphylococcus aureus，MRSA）是院内感染的重要病原菌，烧伤创面一旦发生该种病原菌感染，治疗难度较大。

This article reviews the advance in the re- search of both the mechanism of photodynamic antimicrobial chemotherapy （PACT） based on the principle of photodynamic therapy and the application of PACT in the treatment of methicil- lin-resistant Staphylococcus aureus （ MRSA ） infection. Nowa- days an inexorable prevalence of resistant bacteria observed worldwide, among which MRSA strains typically have a high po- tential of provoking outbreaks with intractability, makes it a pressing issue to develop new germicidal strategies. PACT is an emerging photochemistry-based technology. In the presence of oxygen, PACT, with the aid of the activation of photosensitizers to generate reactive oxygen species by the wavelength-specific light, destroys the structure of bacteria selectively and efficient- ly , with much lower bacterial resistance level than that of antihi- otics. We expect that further research would elucidate the mech- anism and develop clinical applications of PACT, and it may be- come a novel approach to solwe the problem of MRSA infection in the future.