丙戊酸钠对少女癫痫患者性激素的影响

Effect of valproate sodium on genito-endocrine secretion in maidens with epilepsy

目的 分析广谱抗癫痫药物丙戊酸钠（VPA）单药治疗对少女癫痫患者性激素水平的影响。方法 选择自2009年9月至2011年10月南方医科大学附属中山博爱医院儿科收治的少女癫痫患者46例，应用VPA治疗12月，观察患者用药前和用药后睾酮、雌二醇和卵泡刺激素水平的变化。结果 与用药前比较，VPA用药3、6、12个月后，患者雌二醇、卵泡刺激素水平差异均无统计学意义（P〉0．05）；VPA用药12个月时，患者的睾酮水平[（0．5±0．4）ng／mL]较治疗前[0．8±0．3）ng／mL]和治疗3个月时[（0．8±0．3）ng／mL]显著下降，差异有统计学意义（P〈0．05）。结论 VPA用药对少女癫痫患者性激素水平影响不大，仍然是现阶段治疗少女癫痫患者的最佳方案。

Objective To analyze the influence of anti-epileptic drug valproate sodium （VPA） on the level of sex hormone in maidens with epilepsy. Methods Forty-six maidens with epilepsy aged from 8 to 15 years, collected in our hospital from September 2009 to October 2011 and received VPA treatment for 12 months, were chosen in our study. The levels of testosterone, estradiol （E2） and follicle-stimulating hormone （FSH） were surveyed before medication and 3, 6, 12 months after medication. Results The levels of E2 and FSH in maidens with epilepsy during the 12 months of VPA medication showed no significant difference as compared with those before treatment （P〉0.05）; but the level of testosterone 12 months after medication （0.5±0.4 ng/mL） decreased compared with that before treatment （0.8±0.3 ng/mL） and 3 months after medication （0.8 ±0.3 ng/mL） （P〈0.05）. Conclusion VPA has little effect on sex hormone level of maidens with epilepsy, and VPA is the best solution of treating maidens with epilepsy.