骨保护素与高血压和(或)糖尿病患者的心血管风险相关
被引量:3
摘要
骨保护素在肿瘤坏死因子受体家族属于分泌性细胞因子中的一员,与内皮功能紊乱相关。该研究旨在探索2型糖尿病和(或)高血压相关血管病变与血清骨保护素之间的关系。方法:连续人选191例患者(52例2型糖尿病患者、139例高血压不伴糖尿病患者)和54例健康者(对照组),用酶联免疫吸附测定血清骨保护素水平。
出处
《中华高血压杂志》
CAS
CSCD
北大核心
2012年第9期887-887,共1页
Chinese Journal of Hypertension
同被引文献83
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1Simonet WS,Lacey DL,Dunstall CR,et al.Osteoprotegerin:a novel secreted protein involved in the regulation of bone density[J].Cell,1997,89(2):309.
-
2Vidal C,Formosa R,Xuereb-Anastasi A.Functional polymorphisms within the TNFRSF11B(osteoprotegerin)gene increase the risk for low bone mineral density[J].Journal of Molecular Endocrinology,2011,47(3):327-333.
-
3郏蓉,纪立农.老年人BMD与OPG基因启动子区SNPs及骨代谢生化指标的相关分析研究[D].2011年北京医学会内分泌暨糖尿病学分会学术年会论文集,2011:128-129.
-
4Roshandel D,Holliday KL,Pye SR,et al.Influence of polymorphisms in the RANKL/RANK/OPG signaling pathway on volumetric bone mineral density and bone geometry at the forearm in men[J].Calcified Tissue International,2011,89(6):446-455.
-
5Luo Y,Hu Z,Hao J,et al.Significant Associations Between the A163G and G1181C Polymorphisms of the Osteoprotegerin Gene and Risk of Osteoporosis,Especially in Postmenopausal Women:A Meta-Analysis[J].Genetic Testing and Molecular Biomarkers,2014,18(3):211-219.
-
6Chao TH,Yu HN,Huang CC,et al.Opposite associations of osteoprotegerin and ZBTB40 polymorphisms with bone mineral density of the hip in postmenopausal Taiwan Residents women[J].Journal of the Chinese Medical Association,2012,75(7):335-340.
-
7Zhang F,He C,Chen G,et al.Association analyses of osteoprotegerin gene polymorphisms withbone mineral density in Chinese postmenopausal women[J].Med Oncol,2013,30(1):389.
-
8Shen L,Qiu Y,Xing S,et al.Association between osteoprotegerin genetic variants and bone mineral density in Chinese women[J].Int Immunopharmacol,2013,16(2):275-278.
-
9Wang Q,Chen Z,Huang Y,et al.The relationship between osteoprotegerin gene polymorphisms and bone mineral density in Chinese postmenopausal women[J].Int Immunopharmacol,2013,17(2):404-407.
-
10Takács I,Lazáryá,Kósa JP,et al.Allelic variations of RANKL/OPG signaling system are related to bone mineral density and in vivo gene expression[J].European Journal of Endocrinology,2010,162(2):423-431.
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-
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-
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-
3蔡宇,彭启华,何光伦.早期胰岛素强化治疗降低2型糖尿病患者大血管并发症的疗效分析[J].世界复合医学,2019,5(10):162-164. 被引量:6
-
4刘倩茹,李飞.骨保护素在冠心病发生、发展及预后中的研究进展[J].中西医结合心脑血管病杂志,2020,18(7):1078-1082. 被引量:6
-
5周文锐,李琛,刘传颂,朱敏洁,梁兴伦.血清骨保护素与2型糖尿病下肢血管病变的关系[J].临床和实验医学杂志,2020,19(16):1713-1716. 被引量:3
-
6钟荣玉,涂萍,段鹏.RANKL/RANK/OPG信号通路与糖尿病及其并发症的相关研究进展[J].医学综述,2021,27(16):3244-3249. 被引量:1
-
1张韩,李彦明,刘枫,姚新亮,钟晓明,闫成芸,万琪琳.房颤患者左心房内径与血清骨保护素及其受体轴的关系及临床意义[J].临床心血管病杂志,2015,31(3):334-336. 被引量:6
-
2陈艳秋,苟怀宇,杨礼环,蒋玉琼,刘颖.脑梗死患者血清骨保护素水平与颈动脉内膜中层厚度的关系[J].临床内科杂志,2016,33(8):529-531.
-
3丁大伟,包宗明.血清骨保护素和糖化血红蛋白水平与急性冠状动脉综合征的关系探讨[J].蚌埠医学院学报,2013,38(5):542-544.
-
4徐美林,张晓艳,张超,魏璇.血清骨保护素与冠状动脉病变程度的关系研究[J].中华临床医师杂志(电子版),2012,6(13):45-48. 被引量:13
-
5魏涵,夏伟,肖卫,蕾茹.肺动脉高压生化指标的相关性分析[J].海南医学院学报,2014,20(7):930-932. 被引量:3
-
6苏蓉,尤丽英,曾西云,唐树荣,刘云兰,张涛,张鸿青.血清骨保护素与高血压及合并颈动脉粥样硬化的相关性研究[J].中国心血管病研究,2016,14(11):1023-1026. 被引量:2
-
7王小斌,单其俊,马根山,杨志健,朱铁兵,王连生,曹克将,马文珠.冠心病患者血清骨保护素水平研究[J].江苏医药,2004,30(4):300-301. 被引量:1
-
8王小斌,单其俊,马根山,杨志健,朱铁兵,曹克蒋.血清骨保护素水平与冠状动脉病变的关系[J].中国临床康复,2004,8(6):1036-1038. 被引量:5
-
9陈晖,刘伶,陆卫军,刘红燕,徐国玲,颜晓东,焦伟,路文盛,谭小燕,胡映玉.血清骨保护素与2型糖尿病及合并冠心病的关系[J].中国临床新医学,2014,7(1):8-10. 被引量:6
-
10宋红,黄华,王伟,宋斌,王荣,彭瀚元,崔静,郝川.不同性别及年龄因素对原发性骨质疏松症骨代谢指标、血清骨保护素及骨密度影响的研究[J].中国骨质疏松杂志,2015,21(10):1161-1164. 被引量:49