硫化氢与阴茎勃起功能关系研究进展

Hydrogen sulfide and penile erection

硫化氢(H2S)是继NO和CO之后第3种被发现的具有内源性活性的气体信号分子,在哺乳动物体内H2S主要由两种蛋白酶———胱硫醚-β-合酶(CBS)和胱硫醚-γ-裂合酶(CSE)合成产生。H2S在体内具有重要的生理调节功能,它可作用于ATP敏感性钾离子通道(K+-ATP)舒张血管平滑肌,与睾酮及NO协同作用舒张阴茎海绵体平滑肌,促进阴茎勃起等。目前,治疗勃起功能障碍(ED)主要应用选择性的5-型磷酸二酯酶(PDE5)抑制剂,而临床发现PDE5抑制剂对部分ED患者治疗无效,因此,进一步研究H2S在阴茎勃起过程中的调节机制及作用,可能为ED提供了新的治疗途径。

Hydrogen sulfide（H2S） is the third type of active endogenous gaseous signal molecule following nitric oxide（NO） and carbon monoxide（CO）.In mammalians,H2S is mainly synthesized by two proteases,cystathionine-β-synthase（CBS） and cystathionine-γ-lyase（CSE）.H2S plays an essential function of physiological regulation in vivo,and promotes penile erection by acting on the ATP-sensitive potassium channels to relax the vascular smooth muscle as well as by the synergistic effect with testosterone and NO to relax the corpus cavernosum smooth muscle（CCSM）.At present,the selective phosphodiesterase type 5（PDE5） inhibitor is mainly used for the treatment of erectile dysfunction（ED）,but some ED patients fail to respond.Therefore,further studies on the mechanism of H2S regulating penile erection may provide a new way for the management of erectile dysfunction.Natl J Androl,2012,18（9）： 823-826