摘要
目的:探讨维持性血液透析(MHD)患者易合并尿路上皮癌的相关因素、临床诊治特点及预后。方法:回顾性分析我院2005年3月～2009年4月收治的387例MHD患者中并发尿路上皮癌的11例患者临床资料,调查其尿路上皮癌的发生情况、临床诊治特点及预后,分析影响尿路上皮癌发生的危险因素。结果:11例MHD合并尿路上皮癌的临床特点均表现为间断、无痛性肉眼血尿及不同程度的贫血,其中透析龄超过5年者8例,超过3年者2例,15个月者1例。11例均行手术治疗,至今生存6～48个月,平均27.2个月,已有3例死亡,余未见肿瘤复发。Logistic回归分析结果显示透析龄是尿路上皮癌发生的独立危险因素。结论:维持性血液透析患者易合并尿路上皮癌,且透析龄是并发尿路上皮癌的危险因素,早期手术治疗有助于改善预后。
Objective：To investigate the urothelial carcinoma and its related factors, clinical features and prog nosis in patients on maintenance dialysis. Method：We recruited 387 maintenance hemodialysis patients into a study, to investigate the incidence of urothelial carcinoma and the clinical features of the malignancies. We also used logis tic regression analysis method to analyze the tumor-related factors. Result： Among the 387 maintenance hemodialysis patients, l 1 eases（2.84%） developed urothelial carcinoma. All of the patients with urothelial carcinoma presented intermittent and painless gross hematuria and exhibited refractory anemia. This group includes 8 cases with hemodialysis more than 5 years, more than 3 year： 2 cases, there was 1 case with hemodialysis in 15 monthes. All of the patients with urothelial carcinoma were treated with surgery. Whose survival time has been lasted for 6 to 48 months （average 27.2 months）. Three of them died, others have survive with no recurrence. Logistic regres sion analysis showed that age and the time of dialysis was the independent risk factors relating to urothelial carcinoma. Conclusion：The incidence of urothelial carcinoma was high in maintenance hemodialysis patients, the time of dialysis was an independent risk factors relating to urothelial carcinoma. Early diagnosis and operation are essential to improve their prognosis.
出处
《临床泌尿外科杂志》
2012年第10期750-752,755,共4页
Journal of Clinical Urology
