羟丙茶碱药代动力学的研究及其临床监测

The pharmacokinetic study and clinic monitor of proxyphyline

本文以反相高效液相色谱法对5名健康受试者进行了体内羟丙茶碱药代动力学的初步研究,口服400mg单剂量后的血药浓度按单室一级吸收模型拟合药-时曲线,求得各项动力学参数,并对30名患者进行了稳态血药浓度的监测。

The reversed phase HPCC was developed to determine the plasma concentration of proxyphyline in 5 healthy subjectis with a 400mg single dose of proxyphyline. The plasma concentration Was fitted with the Single compartment absorbtion model to con-time curve. The pharamacokintic parameters were obtained and the stable drug concentration in 30 subjects was monitored.