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地佐辛对声门手术患者术后应激及苏醒的影响 被引量:3

Effect of Dezocine on Postoperative Recovery and Surgical Stress Response in Patients with Glottis Surgery
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摘要 目的:观察地佐辛用于支撑喉镜声门手术对患者应激反应、血流动力学、术后苏醒的影响。方法:48例ASAⅠ~Ⅱ级支撑喉镜声门手术患者,随机分为对照(C)组和地佐辛(D)组,每组24例。D组麻醉诱导时给予地佐辛5mg(1mL),C组给予生理盐水1mL。记录2组麻醉期间不同时间点的平均动脉压(MAP)、心率(HR)、拔管时间(停药至拔除气管导管),拔管时躁动评分和镇静评分,测定麻醉前和拔管后即刻的血浆皮质醇浓度。结果:处理因素对MAP、HR影响差异有统计学意义(P〈0.05或P〈0.01),时间与处理因素存在交互作用(P〈0.05),2组HR和MAP的时间效应差异有统计学意义(P〈0.05);2组拔管时间、拔管后镇静评分差异无统计学意义(P〉0.05);D组拔管后躁动评分和血浆皮质醇增高值低于C组(P〈0.05)。结论:术前给予地佐辛可减轻支撑喉镜声门手术患者围术期应激,不延长苏醒时间,降低拔管后躁动,提高苏醒质量。适用于短小手术。 Objective: To study the influence of dezocine in surgical stress response, hemodynamics and postoperative recovery in patients with glottis surgery under laryngoscope. Methods: Forty-eight patients of ASA Ⅰ - Ⅱ grade, underwent glottis surgery, were randomly divided into two groups. (n=24). Patients in control group (C, n=24) received saline (1 mL) and dezocine group (D, n=24) received dezocine (5 mg, 1 mL). The extubation time, mean arterial pressure (MAP), heart rate (HR), RS score, RSS score and values of cortisol levels were recorded in two groups of patients. Results: There were significant differences in MAP and HR between group D and group C (P 〈 0.05 or P 〈 0.01). There was interaction between time and treatment factors (P 〈 0.05). There were significant differences in time effects of MAP and HR between two groups (P 〈 0.05). There were no significant differences in the extubation time and RSS score between two groups (P 〉 0.05). The values of RS score and of plasma cortisol level were significantly lower in group D than those of group C (P 〈 0.05). Conclusion: Preoperative administration of dezocine reduces tracheal extubation-induced adverse effect and improves quality of recovery.
出处 《天津医药》 CAS 北大核心 2012年第10期1019-1021,共3页 Tianjin Medical Journal
关键词 受体 阿片样 喉镜检查 插管法 气管内 应激 血流动力学 地佐辛 receptors, opioid laryngoscopy intubation, intratracheal stress hemodynamics dezocine
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