锁孔手术治疗低级别胶质瘤的远期疗效观察

Long-term outcome of keyhole surgery in the treatment of low-grade glioma:clinical observation

目的探讨锁孔手术治疗低级别胶质瘤的远期疗效。方法回顾性分析85例幕上低级别胶质瘤病人的临床资料,其中传统手术组37例,锁孔手术组48例,对两组病人的手术参数及预后进行统计学分析。结果两组病人的5年生存率、肿瘤全切率及手术时间差异无统计学意义(均P>0.05);术中输血率、并发症发生率、术中平均出血量及术后平均住院时间差异有统计学意义(均P<0.05)。结论对于位置较深、直径≤4 cm的幕上低级别胶质瘤可以采用锁孔手术治疗,远期疗效与较传统手术无差别。

Objective To explore the long-term outcome of keyhole surgery in the treatment of low-grade glioma. Methods Clinical data of 85 patients with supratentodal low-grade glioma were analyzed retrospectively, including 37 patients in traditional surgery group and 48 in keyhole surgery group. The differences in the operative parameters and prognosis between two groups were analyzed statistically. Results Between the two groups, there was no statistical difference in five-year survival rate, rate of tumor complete resection and surgical time （all P 〉 0.05）. There were statistical differences in the rate of intraoperative blood transfusion, incidence of complications, mean intraoperative bleeding volume and mean postoperative hospital stay between two groups （all P 〈 0.05）. Conclusions The supratentorial low-grade glioma which is located deeply with diameter less or equal to 4 cm can be treated by using keyhole surgery. However, there is no difference in the long-term outcome between keyhole surgery and traditional surgery.