阿仑膦酸钠对骨关节炎关节软骨保护作用的研究进展

RESEARCH PROGRESS OF PROTECTIVE EFFECTS OF ALENDRONATE ON ARTICULAR CARTILAGE IN OSTEOARTHRITIS

目的综述阿仑膦酸钠(alendronate,ALN)对骨关节炎(osteoarthritis,OA)关节软骨保护作用的研究进展。方法广泛查阅近年国内外相关文献,并进行综合分析。结果 ALN能改善OA关节软骨代谢微环境,抑制软骨下骨骨重塑,对关节软骨有潜在保护作用。结论 ALN有望成为一种OA疾病改善药物,但OA治疗尚缺乏统一的基础与临床评价标准,制定统一标准并获取临床数据对ALN的开发和应用有指导性意义。

Objective To summarize the recent development on chondroprotective effect of alendronate（ALN） on articular cartilage in osteoarthritis（OA）.Methods The related literature was reviewed and the main achievements in vitro/vivo studies in the fields were summarized.Results ALN can improve the metabolic microenvironment of the articular cartilage in OA,inhibit subchondral bone remodeling,so it has potential protective effect on articular cartilage.Conclusion ALN is expected to become a disease-modifying OA drug in future,but OA treatment still lack a uniform basic and clinical evaluation criteria,so it has guiding signi cance in development and flapplication of ALN to develope a uniform standard and obtain the clinical data.