期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

单侧突发性感音神经性耳聋患者静息状态默认网络的变化 被引量：5

Changes of resting-state default-mode network functional connectivity in patients with unilateral sudden sensorineural hearing loss
原文传递
导出
摘要 目的探索单侧突发性感音神经性耳聋(SSNHL)患者静息状态默认网络的改变。方法选取16例重度左侧突发性感音神经性耳聋患者(耳聋组)和16例健康志愿者(对照组)进行静息状态脑功能磁共振扫描,通过时程相关方法检测fMRI数据低频波动信号中以后扣带回为种子区的默认网络,并进行组间比较。结果耳聋组较正常对照组脑功能连接增强的区域为右侧枕中回,耳聋组较正常对照组脑功能连接减弱的区域为右侧额中回。结论 SSNHL患者在静息状态下存在脑默认网络的功能连接异常。 Objective To explore the changes of resting-state default-mode network functional connectivity in the patients with unilateral sudden sensorineural hearing loss（SSNHL）. Methods The [MRI scanning in resting-state was performed in 16 severe left side SSNHL patients（group A） and 16 healthy volunteers with normal hearing（group B）. The default-mode network based on seed region of posterior cingulated cortex was extracted from low frequency fluctuation signal in fMRI data using a temporal correlation method and compared between two groups. Results Compared with group B, the brain area with increased functional connectivity in group A was the right middle occipital gyrus,while the brain area with decreased functional connectivity was the right middle frontal gyrus. Conclusion The abnormal funtional connectivity of brain defanlt mode network happens to the SSNHL patients in resting state.
作者 季慧 黄志纯 杨明 朱新 孟黎平 李晶
机构地区 南京医科大学附属南京市妇幼保健院儿童保健科 东南大学附属中大医院耳鼻咽喉科 东南大学附属中大医院放射科
出处 《江苏医药》 CAS CSCD 北大核心 2012年第19期2246-2249,共4页 Jiangsu Medical Journal
基金 国家自然科学基金(30070808) 东南大学高校基本科研业务费专项资金(3290001504) 南京市科技发展计划项目(7990000011)
关键词 突发性感音神经性聋 磁共振成像 默认网络 Sudden sensorineural hearing loss Magnetic resonance imaging Default-mode network
分类号 R764 [医药卫生—耳鼻咽喉科]
  • 相关文献

参考文献10

  • 1Firszt JB, Ulmer JL, Gaggl W. Differential representation of speech sounds in the human cerebral hemispheres[J]. Anat Rec A Discov Mol Cell Evol Biol, 2006,288 (4) : 345-357.
  • 2Raichle ME, Snyder AZ. A default mode of brain function: a brief history of an evolving idea[J]. Neuroimage, 2007, 37 (4):1083-1090.
  • 3Raichle ME, Maeleod AM, Snyder AZ, et al. A default mode of brain function[J]. Proc Natl Acad Sci USA, 2001,98 (2): 676-682.
  • 4Gusnard DA, Raichle ME, Raichle ME. Searching for a baseline., functional imaging and the resting human brairl[J]. Natr Rev Neurosci, 2001,2 (10) : 685-694.
  • 5Damoiseaux JS, Rombouts S, Barkhof F, et al. Consistent resting-state networks across healthy subjeets[J]. Proe NatlAcad Sci U S A, 2006,103(37):13848-13853.
  • 6Greicius MD, Krasnow B, Reiss AL, et al. Functional connectivity in the resting brain: a network analysis of the default mode hypothesis[J]. Proc Natl Acad Sci U S A, 2003, 100(1) :253-258.
  • 7Sadato N, Okada T, Honda M, et al. Critical period for cross- modal plasticity in blind humans: a functional MRI study[J]. Neuroimage, 2002,16 (2) ： 389-400.
  • 8Petitto LA, Zatorre RJ, Gauna K, et al. Speech-like cerebral activity in profoundly deaf people processing signedlanguages: Implications for the neural basis of human language[J]. Proc Natl Acad Sci U S A,2000,97(25) :13961- 13966.
  • 9D'Esposito M, Postle BR, Rypma B. Prefrontal cortical contributions to working memory: evidence from event- related flVIRI studies[J]. Exp Brain Res, 2000,133 (1) : 3-11.
  • 10Otten LJ, Rugg MD. Task-dependency of the neural correlates of episodic encoding as measured by fMRI[J]. Cereb Cortex, 2001,11(12) : 1150-1160.

同被引文献56

  • 1突发性聋的诊断和治疗指南(2005年,济南)[J].中华耳鼻咽喉头颈外科杂志,2006,41(8):569-569. 被引量：853
  • 2Korpinar S,Alkan Z,Yigit O,et al. Factors influencing the outcome of idiopathic sudden sensorineural hearing loss treated with hyper- baric oxygen therapy [ J ]. Eur Arch Otorhinolaryngol, 2011,268 (1) :41 -47.
  • 3WU CW, CHEN CL, LIU PY,et al. Empirical evaluations of slice- timing, smoothing, and normalization effects in seed-based, resting- state functional magnetic resonance imaging ananlyses [ J ]. Brain Connect,2011,1 ( 5 ) :401 - 410.
  • 4Wunderlieh AP,Schnfeldt-Leeuona C,Wolf RC,et al. Cortical acti- vation during a pitch discrimination task in tinnitus patients and controls : an fMRI study[ J ]. Audiol Neurootol,2010,15 : 137 - 148.
  • 5Zang YF, He Y, Zhu CZ, et al. Altered baseline brain activity in children with ADHD revealedby resting-state functional MRI [ J ]. Brain Dev,2007,29 (2) : 83 - 91.
  • 6Raichle ME, Macleod AM, Snyder AZ, et al. A default mode of brain function[ J]. Proc Natl Acad Sci USA,2001,98 (2) :676 - 682.
  • 7Syka J. Plastic changes in the central auditory system after hearing loss,restoration of function, and during learing [ J ]. Physiol Rev, 2002,82(3) :601 -636.
  • 8Lenroot RK,Giedd JN. Sex differences in the adolescent brain[ J] Brain cogn ,2010,72 ( 1 ) :46 - 55.
  • 9Middleton FA,Strick PL. Basal ganglia and cerebellar loops: motor and cognitive circuits [ J ]. Brain Res Brain Res Rev, 2000,31 ( 2/ 3 ) :236 - 250.
  • 10Deen B,Pitskel NB, Pelphrey KA. Three systems of insular function- al connectivity identified with cluster analysis [ J ]. Cereb Cortex, 2011,21 (7) :1498 - 1506.

引证文献5

二级引证文献13

江苏医药
2012年 第19期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部