乳杆菌活菌胶囊调整产后阴道菌群失衡的效果

Efficacy of living preparation of lactobacillus in regulating disturbance of vaginal microbial population in women after delivery

目的观察乳杆菌活菌胶囊治疗产后细菌性阴道病(BV)的有效性。方法按Amsel标准对600例产后6-8周妇女进行BV筛查,将确诊BV的356例产妇(哺乳妇女174例,未哺乳妇女182例)随机分为两组:A组178例,采用定君生胶囊阴道给药治疗;B组178例,采用复方甲硝唑栓阴道给药治疗。均连续用药10d,停药7d后复查。选600名正常育龄妇女为对照组。结果产后6-8周妇女BV检出率为59.33%(356/600),明显高于对照组的19.33%(116/600)(P<0.05)。A组治疗BV的总有效率为92.70%,B组为92.13%(P>0.05)。结论产后6-8周妇女BV发病率较高,乳杆菌活菌胶囊能有效改善阴道内生态环境,安全、有效,易为产妇所接受。

Objective To investigate the efficacy of living preparation of lactobacillus in regulating disturbance of vaginal microbial population in women after delivery. Methods A total of 600 post-partum women at 6 to 8 weeks underwent bacterial vaginosis （BV） screening with Amsel standard. Post-partum BV was diagnosed in 356 cases （174 breast-feeding women and 182 without breast-feeding） ,who were equally divided into two groups of A （treated with living preparation of lactobacillus） and B（treated with compound metronidazole suppository）. The treatment lasted for 10 days and examination was repeaded 7 days later. Another 600 women of childbearing age were taken as the controls（group C）. Results The incidence rate of BV in 6 to 8 weeks post-partum women was 59.33^（356/600）, which was significantly higher than 19.33% （116/600） in group C（P^0.05）. The total effectiveness rate of group A was similar to that of group B（92.70% vs. 92.13%）. Conclusion The post-partum women in 6 to 8 weeks after delivery has a higher incidence of BV. Living preparation of lactobacillus can effectively improve the ecological environment of the vagina.