Caveolin-1在下咽鳞癌中的表达及其临床意义

Expression and significance of Caveolin-1 in hypopharyngeal carcinoma

目的研究Caveolin-1在下咽鳞癌组织中的表达情况,探讨其在下咽鳞癌发生发展中的作用机制。方法采用免疫组化法检测Caveolin-1在69例下咽鳞癌及10例癌旁正常组织中的表达,统计分析两者之间的相关性。结果 Caveolin-1在下咽癌组织中的阳性率为34.78%,在对照组中Caveolin-1存在个别表达或无阳性表达,两者表达差异有统计学意义(P<0.05);Caveolin-1的表达程度与病理类型、转移相关,而与下咽鳞癌患者性别、临床分期和原发部位之间差异无统计学意义(P>0.05)。结论下咽鳞癌中Caveolin-1的表达明显增高并与肿瘤的转移行为有关,有可能作为下咽鳞癌预后不良的病理标志之一。

Objective To evaluate the expression of caveolin-1 in hypopharyngeal squamous cell carcinoma(HSCC) and investigate its association with pathological features and clinical outcome.Methods Caveolin-1 expression was determined by immunohistochemistry using rabbit polyclonal antibody against caveolin-1 in 69 paraffin embedded primary HSCC and 10 normal hypopharyngeal mucosa specimens.Associations between caveolin-1 expression and pathological features and clinical outcomes were analyzed with a chi-square test.Results The caveolin-1 expression in HSCC was much higher than in the normal mucosa.The positive rate of caveolin-1 was 0% in the normal mucosa but 34.78% in the primary tumors.Increased caveolin-1 expression had been reported to be associated with various pathological parameters,including higher Gleason score and lymph node metastasis.Although no significant association between caveolin-1 expression and gender or primary position was observed,caveolin-1 was distinctively increased in cases with lymph node metastases(P<0.05).Conclusion Over-expression of Caveolin-1 could be a common finding in the aggressive types of HSCC.Caveolin-1 might play an important role in invasion and metastatic progression of HSCC.