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非小细胞肺癌EML4-ALK融合基因检测的临床意义 被引量：1

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摘要 近年来，靶向药物治疗成为肺癌治疗热点，越来越多的分子靶点的发现及靶向药物的研发给肺癌患者长期生存带来希望。
作者 张宁宁 石远凯
机构地区 北京协和医学院中国医学科学院肿瘤医院肿瘤研究所内科
出处 《中华检验医学杂志》 CAS CSCD 北大核心 2012年第9期862-864,共3页 Chinese Journal of Laboratory Medicine
基金 国家高技术研究发展计划（863计划）资助项目（2011AA02A110） 国家重大新药创制科技重大专项资助项目（2012ZX09303012） 卫生部卫生公益性行业科研专项资助项目（200902002-1） 中央保健资助课题（B2009B124）
关键词 非小细胞肺癌 融合基因检测 临床意义 药物治疗 靶向药物 长期生存 肺癌患者 分子靶点
分类号 R734.2 [医药卫生—肿瘤]
  • 相关文献

参考文献16

  • 1Soda M, Choi YL, Enomoto M, et al. Identification of the transforming EMIA-ALK fusion gene in non-small-cell lung cancer. Nature, 2007,448:561-566.
  • 2Morris SW, Nacre C, Mathew P, et al. ALK, the chromosome 2 gene locus altered by the t (2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kiuase that is highly related to leukocyte tyrosine kinase (LTK). Oncogene, 1997,14 : 2175-2188.
  • 3Koivunen JP, Mermel C, Zejnullahn K, et al. EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer. Clin Cancer Res, 2008,14:4275-4283.
  • 4杨统,刘红雨,陈军.肺癌中EML4-ALK融合基因的存在状态及生物学功能[J].中国肺癌杂志,2012,15(2):112-116. 被引量：2
  • 5Inamura K, Takeuchi K, Togashi Y, et al. EML4-ALK fusion is linked to histological characteristics in a subset of lung cancers. J Thorac Oncol, 2008,3 : 13-17.
  • 6Koivunen JP, Mermel C, Zejnullahu K, et al. EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer. Clin Cancer Res, 2008,14:4275-4283.
  • 7Inamura K, Takeuchi K, Togashi Y, et al. EML4-ALK lung cancers are characterized by rare other mutations, a TTF-1 cell lineage,an acinar histology,and young onset. Mod Pathol, 2009, 22:508-515.
  • 8Martelli MP, Sozzi G, Hemandez L, et al. EML4-ALKRearrangement in Non-Small Cell Lung Cancer and Non-Tumor Lung Tissues. American J Pathol, 2009 ; 174:661-670.
  • 9Shaw AT, Yeap BY, Mino-Kenudson M, et al. Clinical features and outcome of patients with non-small-cell lung cancer who harbor EMIA-ALK. J Clin Oncol, 2009,27:4247-4253.
  • 10Wang DW, Leung EL, Kam-Ting K, et al. The EML4-ALK fusion gene is involved in various histologic types of lung cancers from non-smokers with wild-type EGFR and KRAS. Cancer, 2009, 115:1723-1733.

二级参考文献26

  • 1Mitsudomi T,Morita S,Yatabe Y,et al.Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor(WJTOG3405):an open label, randomised phase 3 trial.Lancet Oncol,2010,11(2):121-128.
  • 2Horn L,Pao W.EML4-ALK:honing in on a new target in non-small-cell lung cancer.J Clin Oncol,2009,27(26):4232-4235.
  • 3Jokoji R,Yamasaki T,Minami S,et al.Combination of morphological feature analysis and immunohistochemistry is useful for screening of EML4-ALK-positive lung adenocarcinoma.J Clin Pathol,2010,63(12):1066-1070.
  • 4Sabbatini P,Korenchuk S,Rowand JL,et al.GSK1838705A inhibits the insulin-like growth factor-1 receptor and anaplastic lymphoma kinase and shows antitumor activity in experimental models of human cancers.Mol Cancer Ther,2009,8(10):2811-2820.
  • 5Shaw AT,Yeap BY,Mino-Kenudson M,et al.Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK J Clin Oncol,2009,27(26):4247-4253.
  • 6Lin E,Li L,Guan Y,et al.Exon array profiling detects EML4-ALK fusion in breast,colorectal,and non-small cell lung cancers.Mol Cancer Res,2009, 7(9):1466-1476.
  • 7Anastasov N,Bonzheim I,Rudelius M,et al.C/EBPbeta expression in ALK-positive anaplastic large cell lymphomas is required for cell proliferation and is induced by the STAT3 signaling pathway.Haematologica,2010,95(5): 760-767.
  • 8Singh RR,Cho-Vega JH,Davuluri Y,et al.Sonic hedgehog signaling pathway is activated in ALK-positive anaplastic large cell lymphoma.Cancer Res,2009,69(6):2550-2558.
  • 9Perner S,Wagner PL,Demichelis F,et al.EML4-ALK fusion lung cancer:a rare acquired event.Neoplasia,2008,10(3):298-302.
  • 10Zhang X,Zhang S,Yang X,et al.Fusion of EML4 and ALK is associated with development of lung adenocarcinomas lacking EGFR and KRAS mutations and is correlated with ALK expression.Mol Cancer,2010,9:188.

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中华检验医学杂志
2012年 第9期

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