TURP治疗前列腺癌下尿路梗阻引发肿瘤血行转移风险的细胞学探索

Cytological basis of hematogenous metastasis by TURP for treating lower urinary tract obstruction due to prostate cancer

目的初步了解TURP治疗前列腺癌术中有无肿瘤血行转移的细胞学基础。方法 2010年6月～2012年5月笔者采用经尿道前列腺肿瘤电切术治疗具有明显排尿梗阻症状的局限性前列腺癌、晚期前列腺癌患者各8例,收集术中电切液并进行离心、涂片、HE染色后观察肿瘤细胞数量。结果 8例晚期前列腺癌患者电切液沉渣中全部发现大量癌细胞,8例局限性前列腺癌患者电切液沉渣中,4例发现大量癌细胞,2例发现大量核异质细胞,2例未见异常细胞。结论行TURP治疗前列腺癌患者电切液中存在大量的癌细胞,具有引发肿瘤血行转移风险的细胞学基础。

Objective To investigate the cytological basis of hematogenous metastasis in transurethral resection of the prostate for treatment of lower urinary tract obstruction due to prostate cancer.Methods From June 2010 to May 2012,16 patients with lower urinary tract obstruction due to prostate cancer treated by TURP.The transurethral lavage fluid of TURP was collected and centrifuged.The number of tumor cells in sediment of the fluid was observed after HE staining.Results A large number of cancer cells were found in the transurethral lavage fluid of all 8 cases of advanced prostate cancer,4 cases of localized prostate cancer.A large number of nuclear heterogeneous cells were found in the transurethral lavage fluid of 2 cases of localized prostate cancer.Conclusion There is cytological basis of hematogenous metastasis in TURP for treatment of lower urinary tract obstruction due to prostate cancer.