西沙必利与多潘立酮分别联合奥美拉唑治疗反流性食管炎的疗效比较

Clinical efficacy of cisapride or domperidone combined with omeprazole in the treatment of reflux esophagitis

目的评价西沙必利与多潘立酮分别联合奥美拉唑两种方法治疗反流性食管炎的疗效。方法将97例患者随机分为两组,其中观察组49例,对照组48例。观察组予奥美拉唑20mg,2次/d,西沙必利10mg,3次/d;对照组给予奥美拉唑20mg,2次/d,多潘立酮10mg,3次/d,两组维持治疗2个月,观察临床症状以及内镜复查结果。结果观察组治疗总有效率为98.0%,内镜检查有效率为95.9%;对照组临床治疗总有效率为87.5%,内镜检查有效率为83.3%,两组比较差异有统计学意义(P<0.05)。结论西沙必利联合奥美拉唑治疗反流性食管炎疗效优于多潘立酮联合奥美拉唑,值得在临床上推广。

Objective To evaluate efficacy of cisapride or domperidone and omeprazole in the treatment of reflux esophagitis.Methods 97 patients were randomly divided into two groups,the observation group（n=49） and control group（n=48）.Patients in observation group were treated with omeprazole 20 mg bid and cisapride 10 mg tid,while patients in control group were treated with omeprazole 20 mg bid and domperidone 10 mg tid.The effects were appraised by clinical observation and endoscopy after two months treatment.Results The total effective rate of the observation group was 98.0% by clinical observation and 95.9% by endoscopy,respectively,while The total effective rate of the control group was 87.5% by clinical observation and 83.3% by endoscopy,respectively,and the difference was statistically significant（P 0.05）.Conclusion Cisapride and omeprazole are better than domperidone and omeprazole in the treatment of reflux esophagitis.