以溃疡、糜烂、痤疮样萎缩性瘢痕为主要表现的播散性盘状红斑狼疮1例

Disseminated discoid lupus edrythematosus presenting an ulcer,erosion and acne-like atrophy scar

患者因面部红斑丘疹于笔者所在门诊行皮肤病理检查,确诊盘状红斑狼疮。2011年3月患者外伤骨折术后皮疹加重,累及头皮、双手。新发皮损主要表现为溃疡、糜烂,陈旧皮损主要表现为痤疮样萎缩性瘢痕。2011年6月再次皮肤病理检查符合盘状红斑狼疮改变,结合临床、免疫等辅助检查,排除系统性红斑狼疮,诊断播散性盘状红斑狼疮。治疗予硫酸羟氯喹口服、复方甘草酸苷静点等,疗效明显。患者免疫检查抗β2-GP1抗体阳性,考虑新发皮损溃疡、糜烂的表现与此相关。

A patient who presented with red macules and palpues on her face had been diagnosed DLE.Histopathologic examination verified the diagnosis.The lesions had been aggravated and affected scalp and hands after bone fracture in March 2011.The most manifestation is ulcer and erosion.The old lesion presents with acne-like atrophy scar.The clinical diagnosis of DDLE was supported by another histology,clinical manifestation and immune test in June 2011.And SLE has been excluded.Hydroxychloroquine and compound givcyrrhlzln injection has been applied and they are effective.Immunological examination in patients was anti-β 2-GP1 antibodies which was considered be related to performance of new hair lesions ulcers and the erosion.