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卷烟烟气中4-N-亚硝基甲基氨-1-(3-吡啶基)-1-丁酮的量化健康风险评估 被引量：2

Quantitative health risk assessment of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in cigarette smoke
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摘要 目的：对卷烟烟气中4-N-亚硝基甲基氨-1-（3-吡啶基）-1-丁酮（NNK）进行量化健康风险评估,为化合物的风险评估提供新的思路和方法。方法：运用健康风险评估基本框架,采用模拟与风险分析方法,对暴露参数进行概率分布模拟,并采用不同风险分析方法对NNK的风险进行评估。结果：采用二维和一维模拟得到NNK的风险评估终生癌症风险增量（ILCR）值分别为6.66×10^4和1.29×10^4,其致癌风险需引起关注,并给予管控,灵敏度分析表明NNK释放量对风险影响较大。结论：NNK的释放量对致癌风险贡献较高,需引起高度关注。 OBJECTIVE：To provide the new insight into the quantitative health risk assessment on 4- （melhylnitrosamino）-1-（3-pyridyl）-1-butanone（NNK） in cigarette smoke.METHODS：Using the basic frame of health risk assessment and simulation and risk analysis,the probability distribution of exposure parameters were filled,NNK incremental lifetime cancer risk（ILCR） was simulated by 2D simulation and 1D simulation.RESULTS：ILCR values,the calculated risks of NNK,were 6.66×10^-4 and 1.29×10^-4 and NNK should be highly controlled.And NNK release exerted a great influence on ILCR.CONCLUSION：We should be highly concerned about NNK and its carcinogenic risk.
作者 尚平平 李翔 聂聪 郭军伟 赵乐 刘惠民 谢剑平 陈小玉
机构地区 郑州烟草研究院 郑州大学公共卫生学院
出处 《癌变．畸变．突变》 CAS CSCD 2012年第5期340-344,共5页 Carcinogenesis,Teratogenesis & Mutagenesis
基金 国家自然科学基金项目(21007094) 中国科学技术部项目(2012BAK01B00)
关键词 卷烟烟气 4-N-亚硝基甲基氨-1-(3-吡啶基)-1-丁酮 量化健康风险评估 cigarette smoke 4-（methylnitrosamino）-1-（3-pyridyl）-1-butanone quantitative health risk assessment
分类号 R994.6 [医药卫生—毒理学]
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共引文献311

同被引文献69

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引证文献2

二级引证文献11

癌变．畸变．突变
2012年 第5期

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